Issue 24, 2009

2,3-Functionalization of furans, benzofurans and thiophenesvia magnesiation and sulfoxide–magnesium exchange

Abstract

The use of TMPMgCl·LiCl and iPrMgCl·LiCl allows a sequential 2,3-difunctionalization of various 2-arylsulfinyl furans, thiophenes and benzofurans. Subsequent use of the same reagents permits a selective full functionalization of all 4 positions of the furan and thiophene scaffolds.

Graphical abstract: 2,3-Functionalization of furans, benzofurans and thiophenes via magnesiation and sulfoxide–magnesium exchange

Supplementary files

Article information

Article type
Communication
Submitted
09 Apr 2009
Accepted
13 May 2009
First published
20 May 2009

Chem. Commun., 2009, 3536-3538

2,3-Functionalization of furans, benzofurans and thiophenes via magnesiation and sulfoxide–magnesium exchange

L. Melzig, C. B. Rauhut and P. Knochel, Chem. Commun., 2009, 3536 DOI: 10.1039/B907330B

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