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Issue 23, 2009
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Recognition of anti-mycolic acid antibody at self-assembled mycolic acid antigens on a gold electrode: a potential impedimetric immunosensing platform for active tuberculosis

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Abstract

Electrochemical impedimetric recognition by anti-mycolic acid antibodies, present in tuberculosis (TB)-positive human serum co-infected with human immunodeficiency virus (HIV), of mycolic acids (MA) integrated into a self-assembled monolayer of N-(2-mercaptoethyl)octadecanamide on a gold electrode is described, proving that the MA-based electrode can satisfactorily discriminate between a TB-positive and a TB-negative serum, thus offering promise as a potential impedimetric immunosensing platform for active tuberculosis.

Graphical abstract: Recognition of anti-mycolic acid antibody at self-assembled mycolic acid antigens on a gold electrode: a potential impedimetric immunosensing platform for active tuberculosis

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Publication details

The article was received on 13 Mar 2009, accepted on 28 Apr 2009 and first published on 15 May 2009


Article type: Communication
DOI: 10.1039/B905192A
Chem. Commun., 2009, 3345-3347

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    Recognition of anti-mycolic acid antibody at self-assembled mycolic acid antigens on a gold electrode: a potential impedimetric immunosensing platform for active tuberculosis

    N. S. Mathebula, J. Pillay, G. Toschi, J. A. Verschoor and K. I. Ozoemena, Chem. Commun., 2009, 3345
    DOI: 10.1039/B905192A

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