Issue 22, 2009

A new bifunctional chelator for copperradiopharmaceuticals: a cage amine ligand with a carboxylate functional group for conjugation to peptides

Abstract

A new sarcophagine cage amine ligand with a pendent carboxylate functional group has been synthesised; the ligand has been conjugated to tumour targeting peptides ([Tyr3]-octreotate and [Lys3]-bombesin) and the conjugates radiolabelled with copper-64.

Graphical abstract: A new bifunctional chelator for copper radiopharmaceuticals: a cage amine ligand with a carboxylate functional group for conjugation to peptides

Supplementary files

Article information

Article type
Communication
Submitted
18 Feb 2009
Accepted
08 Apr 2009
First published
23 Apr 2009

Chem. Commun., 2009, 3237-3239

A new bifunctional chelator for copper radiopharmaceuticals: a cage amine ligand with a carboxylate functional group for conjugation to peptides

M. T. Ma, J. A. Karas, J. M. White, D. Scanlon and P. S. Donnelly, Chem. Commun., 2009, 3237 DOI: 10.1039/B903426A

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