Issue 25, 2009
From the journal:

Chemical Communications

Nucleic acid-induced self-assembly of a platinum(ii) terpyridyl complex: detection of G-quadruplex formation and nuclease activity†

Cong Yu,a   Kenneth Hoi-Yiu Chan,a   Keith Man-Chung Wonga  and  Vivian Wing-Wah Yam*a  

* Corresponding authors

a Centre for Carbon-Rich Molecular and Nanoscale Metal-Based Materials Research, Department of Chemistry and HKU-CAS Joint Laboratory on New Materials, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China
E-mail: wwyam@hku.hk
Fax: +852 2857-1586

Abstract

A simple “proof-of-principle” concept for the monitoring of G-quadruplex formation and nuclease activity based on the unique self-assembly properties of a platinum(II) terpyridyl complex, has been demonstrated.

Graphical abstract: Nucleic acid-induced self-assembly of a platinum(ii) terpyridyl complex: detection of G-quadruplex formation and nuclease activity

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Article information

DOI
https://doi.org/10.1039/B903080H
Article type
Communication
Submitted
13 Feb 2009
Accepted
09 Apr 2009
First published
12 May 2009

Chem. Commun., 2009, 3756-3758

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Nucleic acid-induced self-assembly of a platinum(II) terpyridyl complex: detection of G-quadruplex formation and nuclease activity

C. Yu, K. H. Chan, K. M. Wong and V. W. Yam, Chem. Commun., 2009, 3756 DOI: 10.1039/B903080H

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