Issue 27, 2009
From the journal:

Chemical Communications

Biarylpolyamides as a new class of DNA quadruplex-binding ligands†

Khondaker M. Rahman,a   Anthony P. Reszka,b   Mekala Gunaratnam,b   Shozeb M. Haider,b   Philip W. Howard,a   Keith R. Fox,c   Stephen Neidle*b  and  David E. Thurston*a  

* Corresponding authors

a Gene Targeted Drug Design Research Group, The School of Pharmacy, University of London, 29/39 Brunswick Square, London, UK
E-mail: david.thurston@pharmacy.ac.uk
Fax: +44 (0)20 7753 5964
Tel: +44 (0)20 7753 5931

b CRUK Biomolecular Structure Group, The School of Pharmacy, University of London, 29/39 Brunswick Square, London, UK
E-mail: stephen.neidle@pharmacy.ac.uk
Fax: +44 (0)20 7753 5970
Tel: +44 (0)20 7753 5971

c School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton, UK

Abstract

We report a novel class of biaryl polyamides highly selective for G-quadruplex DNA, and with significant cytotoxicity in several cancer cell lines; they form planar U-shaped structures that match the surface area dimensions of a terminal G-quartet in quadruplex structures rather than the grooves of duplex DNA.

Graphical abstract: Biaryl polyamides as a new class of DNA quadruplex-binding ligands

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Article information

DOI
https://doi.org/10.1039/B902359C
Article type
Communication
Submitted
04 Feb 2009
Accepted
08 May 2009
First published
05 Jun 2009

Chem. Commun., 2009, 4097-4099

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Biaryl polyamides as a new class of DNA quadruplex-binding ligands

K. M. Rahman, A. P. Reszka, M. Gunaratnam, S. M. Haider, P. W. Howard, K. R. Fox, S. Neidle and D. E. Thurston, Chem. Commun., 2009, 4097 DOI: 10.1039/B902359C

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