Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 21st October 2020 from 07:00 AM to 07:00 PM (BST).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 21, 2009
Previous Article Next Article

The ratio of cholesterol 5,6-secosterols formed from ozone and singlet oxygen offers insight into the oxidation of cholesterolin vivo

Author affiliations

Abstract

Ongoing efforts to unravel the origins of the cholesterol 5,6-secosterols (1a and 1b) in biological systems have revealed that the two known chemical routes to these oxysterols, ozonolysis of cholesterol (3) and Hock-cleavage of 5-α-hydroperoxycholesterol (4a), are distinguishable based upon the ratio of the hydrazone derivatives (2a and 2b) formed in each case and this ratio offers an insight into the chemical origin of the secosterols in vivo.

Graphical abstract: The ratio of cholesterol 5,6-secosterols formed from ozone and singlet oxygen offers insight into the oxidation of cholesterolin vivo

Back to tab navigation

Supplementary files

Article information


Submitted
02 Dec 2008
Accepted
11 Mar 2009
First published
16 Apr 2009

Chem. Commun., 2009, 3098-3100
Article type
Communication

The ratio of cholesterol 5,6-secosterols formed from ozone and singlet oxygen offers insight into the oxidation of cholesterolin vivo

A. D. Wentworth, B. Song, J. Nieva, A. Shafton, S. Tripurenani and P. Wentworth Jr., Chem. Commun., 2009, 3098
DOI: 10.1039/B821584G

Social activity

Search articles by author

Spotlight

Advertisements