Issue 13, 2009
From the journal:

Chemical Communications

Chemoenzymatic syntheses of carbasugar analogues of nucleoside diphosphate sugars: UDP-carba-Gal, UDP-carba-GlcNAc, UDP-carba-Glc, and GDP-carba-Man†‡

Kyung-Chang Seo,a   Young-Geol Kwon,a   Dae-Hee Kim,b   In-Sook Jang,c   Jin-Won Choc  and  Sung-Kee Chung*a  

* Corresponding authors

a Department of Chemistry, Pohang University of Sciecnce and Technology, Pohang, Korea
E-mail: skchung@postech.edu
Fax: (+82) 54-279-3399

b GeneChem Inc., Daejeon, Korea

c Department of Biology, Yonsei University, Seoul, Korea

Abstract

Chemoenzymatic syntheses of several NDP-carba-sugars have been successfully carried out, and these essential cofactor analogues are expected to be selective inhibitors of glycosyltransferase enzymes.

Graphical abstract: Chemoenzymatic syntheses of carbasugar analogues of nucleoside diphosphate sugars: UDP-carba-Gal, UDP-carba-GlcNAc, UDP-carba-Glc, and GDP-carba-Man

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Article information

DOI
https://doi.org/10.1039/B821058F
Article type
Communication
Submitted
25 Nov 2008
Accepted
09 Jan 2009
First published
06 Feb 2009

Chem. Commun., 2009, 1733-1735

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Chemoenzymatic syntheses of carbasugar analogues of nucleoside diphosphate sugars: UDP-carba-Gal, UDP-carba-GlcNAc, UDP-carba-Glc, and GDP-carba-Man

K. Seo, Y. Kwon, D. Kim, I. Jang, J. Cho and S. Chung, Chem. Commun., 2009, 1733 DOI: 10.1039/B821058F

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