Issue 14, 2009
From the journal:

Chemical Communications

Photoresponsive tandem zinc finger peptide†

Akiko Nomuraa  and  Akimitsu Okamoto*a  

* Corresponding authors

a Advanced Science Institute, RIKEN (The Institute of Physical and Chemical Research), Wako, Saitama, Japan
E-mail: aki-okamoto@riken.jp
Fax: +81 (0)48 467 9238
Tel: +81 (0)48 467 9205

Abstract

A photoresponsive tandem zinc finger peptide has been synthesized by attaching an azobenzene unit at its N-terminus resulting in a conjugate that retained a high binding ability toward the target DNA sequence, whereas it showed a significant decrease in DNA-binding ability after photoisomerization by UV irradiation to switch off the inhibition function from the DNA-binding protein.

Graphical abstract: Photoresponsive tandem zinc finger peptide

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Article information

DOI
https://doi.org/10.1039/B819838A
Article type
Communication
Submitted
06 Nov 2008
Accepted
03 Feb 2009
First published
20 Feb 2009

Chem. Commun., 2009, 1906-1908

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Photoresponsive tandem zinc finger peptide

A. Nomura and A. Okamoto, Chem. Commun., 2009, 1906 DOI: 10.1039/B819838A

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