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Issue 14, 2009
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The first asymmetric Sonogashira coupling for the enantioselective generation of planar chirality in paracyclophanes

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Abstract

The double Sonogashira coupling of diiodoparacyclophanes with alkynes proceeded to give planarly chiral dialkynylparacyclophanes; a chiral Pd catalyst, which was prepared in situ from PdCl2(CH3CN)2 and Taniaphos, realized the first asymmetric Sonogashira coupling with up to ca. 80% ee.

Graphical abstract: The first asymmetric Sonogashira coupling for the enantioselective generation of planar chirality in paracyclophanes

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Article information


Submitted
24 Oct 2008
Accepted
14 Jan 2009
First published
24 Feb 2009

Chem. Commun., 2009, 1870-1872
Article type
Communication

The first asymmetric Sonogashira coupling for the enantioselective generation of planar chirality in paracyclophanes

K. Kanda, T. Koike, K. Endo and T. Shibata, Chem. Commun., 2009, 1870
DOI: 10.1039/B818904H

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