Issue 6, 2009

Molecular recognition of a thymine bulge by a high affinity, deazaguanine-based hydrogen-bonding ligand

Abstract

7-Deazaguanine (7-DeG) was developed as a hydrogen-bonding module capable of enhanced recognition of uracil (U) and thymine (T); a water-soluble derivative displayed high affinity and selectivity toward DNA and RNA duplexes containing single T- and U-bulges.

Graphical abstract: Molecular recognition of a thymine bulge by a high affinity, deazaguanine-based hydrogen-bonding ligand

Supplementary files

Article information

Article type
Communication
Submitted
08 Oct 2008
Accepted
04 Nov 2008
First published
08 Dec 2008

Chem. Commun., 2009, 668-670

Molecular recognition of a thymine bulge by a high affinity, deazaguanine-based hydrogen-bonding ligand

H. C. Ong, J. F. Arambula, S. Rao Ramisetty, A. M. Baranger and S. C. Zimmerman, Chem. Commun., 2009, 668 DOI: 10.1039/B817733N

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