Issue 48, 2008

6,7-Dimethyllumazine as a potential ligand for selective recognition of adenine opposite an abasic site in DNA duplexes

Abstract

6,7-Dimethyllumazine more selectively binds to adenine (A) base opposite the abasic site in DNA duplexes (5′-TCC AG[X with combining low line] GCA AC-3′/3′-AGG TC[N with combining low line] CGT TG-5′, [X with combining low line] = AP site (Spacer C3), [N with combining low line] = A, T, C and G) than the other three nucleobases with a dissociation constant Kd of ca. 1.0 μM; substituted methyl groups enhance the binding affinity to A and the selectivity for A over T, compared to the parent molecule, lumazine.

Graphical abstract: 6,7-Dimethyllumazine as a potential ligand for selective recognition of adenine opposite an abasic site in DNA duplexes

Supplementary files

Article information

Article type
Communication
Submitted
26 Sep 2008
Accepted
20 Oct 2008
First published
12 Nov 2008

Chem. Commun., 2008, 6588-6590

6,7-Dimethyllumazine as a potential ligand for selective recognition of adenine opposite an abasic site in DNA duplexes

Z. Ye, B. Rajendar, D. Qing, S. Nishizawa and N. Teramae, Chem. Commun., 2008, 6588 DOI: 10.1039/B816876H

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