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Issue 48, 2008
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Glycosylated asterisks are among the most potent low valency inducers of Concanavalin A aggregation

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Abstract

A new class of sulfurated, semi-rigid, radial and low-valent glycosylated asterisk ligands with potential dual function as ligand and probe has some of the highest inhibition potencies of Con A-induced hemagglutination, by using a cross-linking mechanism of Con A which amplifies the enhancement to near nanomolar concentrations with the α-D-mannose asterisk.

Graphical abstract: Glycosylated asterisks are among the most potent low valency inducers of Concanavalin A aggregation

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Article information


Submitted
26 Aug 2008
Accepted
30 Sep 2008
First published
07 Nov 2008

Chem. Commun., 2008, 6507-6509
Article type
Communication

Glycosylated asterisks are among the most potent low valency inducers of Concanavalin A aggregation

M. Sleiman, A. Varrot, J. Raimundo, M. Gingras and P. G. Goekjian, Chem. Commun., 2008, 6507
DOI: 10.1039/B814816C

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