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Issue 43, 2008
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A genetic selection system for evolving enantioselectivity of enzymes

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Abstract

As an alternative to screening in the directed evolution of enantioselective enzymes, a selection system has been implemented for a lipase-catalyzed hydrolytic kinetic resolution of a chiral ester.

Graphical abstract: A genetic selection system for evolving enantioselectivity of enzymes

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Article information


Submitted
20 Aug 2008
Accepted
03 Sep 2008
First published
22 Sep 2008

Chem. Commun., 2008, 5502-5504
Article type
Communication

A genetic selection system for evolving enantioselectivity of enzymes

M. T. Reetz, H. Höbenreich, P. Soni and L. Fernández, Chem. Commun., 2008, 5502
DOI: 10.1039/B814538E

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