Issue 47, 2008
From the journal:

Chemical Communications

Caesium fluoride-promoted Stille coupling reaction: an efficient synthesis of 9Z-retinoic acid and its analogues using a practical building block†

Takashi Okitsu,a   Kinya Iwatsukaa  and  Akimori Wada*a  

* Corresponding authors

a Department of Organic Chemistry for Life Science, Kobe Pharmaceutical University, 4-19-1, Motoyamakita-machi, Higashinada-ku, Kobe 658-8558, Japan
E-mail: a-wada@kobepharma-u.ac.jp
Fax: +81 78 441 7562
Tel: +81 78 441 7560

Abstract

A highly efficient and rapid total synthesis of 9Z-retinoic acid was accomplished by caesium fluoride-promoted Stille coupling reaction; using a common building block, 9Z-retinoic acid analogues were also prepared by the same method without isomerisation of the Z-double bond.

Graphical abstract: Caesium fluoride-promoted Stille coupling reaction: an efficient synthesis of 9Z-retinoic acid and its analogues using a practical building block

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Article information

DOI
https://doi.org/10.1039/B813760A
Article type
Communication
Submitted
07 Aug 2008
Accepted
23 Sep 2008
First published
23 Oct 2008

Chem. Commun., 2008, 6330-6332

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Caesium fluoride-promoted Stille coupling reaction: an efficient synthesis of 9Z-retinoic acid and its analogues using a practical building block

T. Okitsu, K. Iwatsuka and A. Wada, Chem. Commun., 2008, 6330 DOI: 10.1039/B813760A

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