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Issue 41, 2008
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99m-Technetium carbohydrate conjugates as potential agents in molecular imaging

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Abstract

This feature article covers recent reports of work towards the development of 99mTc–carbohydrate based agents for use in SPECT imaging, particularly of cancerous tissue. An outline of some of the key biological functions and coordination chemistry of carbohydrates is given, along with an introduction to bioconjugation and molecular imaging. Technetium coordination chemistry and the subset of this involving bioconjugates are discussed before moving into the focus of the article: glycoconjugates of 99mTc(V) and the more recently developed [99mTc(I)(CO)3]+. Significant work in the last decade has featured the very attractive [99mTc(CO)3]+ core, and the ligand sets designed for this core are discussed in detail.

Graphical abstract: 99m-Technetium carbohydrate conjugates as potential agents in molecular imaging

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Publication details

The article was received on 03 Jun 2008, accepted on 10 Jul 2008 and first published on 12 Sep 2008


Article type: Feature Article
DOI: 10.1039/B809365B
Chem. Commun., 2008, 5077-5091

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    99m-Technetium carbohydrate conjugates as potential agents in molecular imaging

    M. L. Bowen and C. Orvig, Chem. Commun., 2008, 5077
    DOI: 10.1039/B809365B

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