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Issue 34, 2008
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Petrobactinbiosynthesis: AsbB catalyzes condensation of spermidine with N8-citryl-spermidine and its N1-(3,4-dihydroxybenzoyl) derivative

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Abstract

The AsbB enzyme, which is involved in the biosynthesis of the virulence-conferring siderophorepetrobactin in Bacillus anthracis, is shown to catalyze efficient ATP-dependent condensation of spermidine, but not N1-(3,4-dihydroxbenzoyl)-spermidine, with N8-citryl-spermidine or N1-(3,4-dihydroxbenzoyl)-N8-citryl-spermidine, suggesting that N1-(3,4-dihydroxbenzoyl)-spermidine is very unlikely to be a significant intermediate in petrobactinbiosynthesis, contrary to previous suggestions.

Graphical abstract: Petrobactin biosynthesis: AsbB catalyzes condensation of spermidine with N8-citryl-spermidine and its N1-(3,4-dihydroxybenzoyl) derivative

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Article information


Submitted
03 Jun 2008
Accepted
23 Jul 2008
First published
31 Jul 2008

Chem. Commun., 2008, 4034-4036
Article type
Communication

Petrobactin biosynthesis: AsbB catalyzes condensation of spermidine with N8-citryl-spermidine and its N1-(3,4-dihydroxybenzoyl) derivative

D. Oves-Costales, N. Kadi, M. J. Fogg, L. Song, K. S. Wilson and G. L. Challis, Chem. Commun., 2008, 4034
DOI: 10.1039/B809353A

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