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Issue 41, 2008
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Functional biomimetic models for the active site in the respiratory enzyme cytochrome c oxidase

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Abstract

A functional analog of the active site in the respiratory enzyme, cytochrome c oxidase (CcO) reproduces every feature in CcO's active site: a myoglobin-like heme (heme a3), a distal tridentate imidazole copper complex (CuB), a phenol (Tyr244), and a proximal imidazole. When covalently attached to a liquid-crystalline SAM film on an Au electrode, this functional model continuously catalyzes the selective four-electron reduction of dioxygen at physiological potential and pH, under rate-limiting electron flux (as occurs in CcO).

Graphical abstract: Functional biomimetic models for the active site in the respiratory enzyme cytochrome c oxidase

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Publication details

The article was received on 12 May 2008, accepted on 30 Jul 2008 and first published on 04 Sep 2008


Article type: Feature Article
DOI: 10.1039/B808070B
Chem. Commun., 2008, 5065-5076

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    Functional biomimetic models for the active site in the respiratory enzyme cytochrome c oxidase

    J. P. Collman and R. A. Decréau, Chem. Commun., 2008, 5065
    DOI: 10.1039/B808070B

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