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Issue 33, 2008
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Facile and highly efficient synthesis of fluorinated heterocycles via Prins cyclization in ionic liquid hydrogen fluoride salts

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Abstract

Prins cyclization of homoallylic alcohols, thiols, and amines with various aldehydes in an ionic liquid HF salt (Et4NF·5HF) afforded the corresponding 4-fluorinated heterocycles in excellent yields.

Graphical abstract: Facile and highly efficient synthesis of fluorinated heterocycles via Prins cyclization in ionic liquid hydrogen fluoride salts

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Publication details

The article was received on 16 Apr 2008, accepted on 08 May 2008 and first published on 24 Jun 2008


Article type: Communication
DOI: 10.1039/B806389C
Chem. Commun., 2008, 3876-3878

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    Facile and highly efficient synthesis of fluorinated heterocycles via Prins cyclization in ionic liquid hydrogen fluoride salts

    Y. Kishi, H. Nagura, S. Inagi and T. Fuchigami, Chem. Commun., 2008, 3876
    DOI: 10.1039/B806389C

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