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Issue 25, 2008
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A potential role for protein tyrosine phosphatase inhibition by a RuIII–edta complex (edta = ethylenediaminetetraacetate) in its biological activity

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Abstract

[RuIII(edta)(OH2/OH)]1−/2− (edta = ethylenediaminetetraacetate) inhibits protein tyrosine phosphatase (PTP) at physiological pH values in a mechanism that involves binding of the Cys residue of the catalytic domain of the enzyme and similar interactions may be important in the anti-cancer properties of the active forms of many Ru pro-drugs.

Graphical abstract: A potential role for protein tyrosine phosphatase inhibition by a RuIII–edta complex (edta = ethylenediaminetetraacetate) in its biological activity

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Publication details

The article was received on 26 Feb 2008, accepted on 03 Apr 2008 and first published on 28 May 2008


Article type: Communication
DOI: 10.1039/B803261K
Chem. Commun., 2008, 2864-2866

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    A potential role for protein tyrosine phosphatase inhibition by a RuIII–edta complex (edta = ethylenediaminetetraacetate) in its biological activity

    D. Chatterjee, A. Mitra, A. Levina and P. A. Lay, Chem. Commun., 2008, 2864
    DOI: 10.1039/B803261K

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