Combination iminium, enamine and copper(i) cascade catalysis: a carboannulation for the synthesis of cyclopentenes

Abstract

A one-pot, multistep reaction cascade to cyclopentenes from α,β-unsaturated ketones and propargylated carbon acids through a combination of organocatalysis and transition metal ion catalysis is reported; the reaction cascade is simple to perform, occurs under mild conditions and is broad in scope.