TiO2nanoparticles as a soft X-ray molecular probe

Jared M. Ashcroft; Weiwei Gu; Tierui Zhang; Steven M. Hughes; Keith B. Hartman; Cristina Hofmann; Antonios G. Kanaras; David A. Kilcoyne; Mark Le Gros; Yadong Yin; A. Paul Alivisatos; Carolyn A. Larabell

doi:10.1039/B801392F

TiO₂nanoparticles as a soft X-ray molecular probe†

Jared M. Ashcroft,^a Weiwei Gu,^b Tierui Zhang,^c Steven M. Hughes,^d Keith B. Hartman,^e Cristina Hofmann,^e Antonios G. Kanaras,‡^d David A. Kilcoyne,^f Mark Le Gros,^a Yadong Yin,^c A. Paul Alivisatos^d and Carolyn A. Larabell*^ab

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* Corresponding authors

^a Physical Bioscience Division, Lawrence Berkeley National Laboratory, Berkeley, USA
E-mail: carolyn.larabell@ucsf.edu
Fax: +1-510-486-5664

^b Department of Anatomy, University of California, San Francisco, USA

^c Department of Chemistry, University of California, Riverside, USA

^d Department of Chemistry, University of California, Berkeley, USA

^e Department of Chemistry, Rice University, USA

^f Advanced Light Source, Lawrence Berkeley National Laboratory, USA

Abstract

This communication reports the development of a TiO₂–streptavidin nanoconjugate as a new biological label for X-ray bio-imaging applications; this new probe, used in conjunction with the nanogold probe, will make it possible to obtain quantitative, high-resolution information about the location of proteins using X-ray microscopy.

Chemical Communications

TiO₂nanoparticles as a soft X-ray molecular probe†

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TiO₂nanoparticles as a soft X-ray molecular probe

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Chemical Communications