Issue 17, 2008
From the journal:

Chemical Communications

Rational design of cationic cyclooligosaccharides as efficient gene delivery systems†

Alejandro Díaz-Moscoso,a   Patricia Balbuena,b   Marta Gómez-García,b   Carmen Ortiz Mellet,*b   Juan M. Benito,a   Loïc Le Gourriérec,c   Christophe Di Giorgio,c   Pierre Vierling,*c   Antonino Mazzaglia,d   Norberto Micali,e   Jacques Defaye*f  and  José M. García Fernández*a  

* Corresponding authors

a Instituto de Investigaciones Químicas, CSIC, Américo Vespucio 49, Isla de la Cartuja, Sevilla, Spain
E-mail: jogarcia@iiq.csic.es
Fax: +34-954460565
Tel: +34-954489559

b Departamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, Apartado 553, Sevilla, Spain
E-mail: mellet@us.es
Fax: +34 954624960
Tel: +34 954551519

c LCMBA UMR 6001CNRS – Université de Nice Sophia Antipolis, 28, Avenue de Valrose, Nice, France
E-mail: Pierre.Vierling@unice.fr
Fax: +33-476041013
Tel: +33-492076151

d CNR-Istituto per lo Studio dei Materiali Nanostrutturati, c/o Dipartimento di Chimica Inorganica, Chimica Analytica e Chimica Fisica, Università di Messina, Salita Sperone 31, Messina, Italy

e CNR-Istituto per i Processi Chimico Fisici, Salita Sperone, Contrada Papardo, Faro Superiore, Messina, Italy

f Dépt. de Pharmacochimie Moleculaire, Institut de Chimie Moléculaire de Grenoble, (CNRS – Univ. de Grenoble, UMR 5063, FR 2607), Bât. E André Rassat, BP 53, Grenoble, France
E-mail: Jacques.Defaye@ujf-grenoble.fr
Fax: +33-476635313
Tel: +33-476635323

Abstract

Self-assembled cyclodextrin (CD)–DNA nanoparticles (CDplexes) exhibiting transfection efficiencies significantly higher than PEI-based polyplexes have been prepared from homogeneous seven-fold symmetric polyaminothiourea amphiphiles constructed on a β-cyclodextrin scaffold.

Graphical abstract: Rational design of cationic cyclooligosaccharides as efficient gene delivery systems

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Article information

DOI
https://doi.org/10.1039/B718672J
Article type
Communication
Submitted
03 Dec 2007
Accepted
29 Jan 2008
First published
25 Feb 2008

Chem. Commun., 2008, 2001-2003

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Rational design of cationic cyclooligosaccharides as efficient gene delivery systems

A. Díaz-Moscoso, P. Balbuena, M. Gómez-García, C. Ortiz Mellet, J. M. Benito, L. Le Gourriérec, C. Di Giorgio, P. Vierling, A. Mazzaglia, N. Micali, J. Defaye and J. M. García Fernández, Chem. Commun., 2008, 2001 DOI: 10.1039/B718672J

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