Issue 7, 2008
From the journal:

Chemical Communications

Facile synthesis of 3-(aminomethyl)isoquinolines by copper-catalysed domino four-component coupling and cyclisation†

Yusuke Ohta,a   Shinya Oishi,a   Nobutaka Fujii*a  and  Hiroaki Ohno*a  

* Corresponding authors

a Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan
E-mail: nfujii@pharm.kyoto-u.ac.jp, hohno@pharm.kyoto-u.ac.jp

Abstract

Copper(I)-catalysed domino four-component coupling–cyclisation using 2-ethynylbenzaldehydes, paraformaldehyde, secondary amine, and t-BuNH2 in DMF leads to direct and efficient formation of 3-(aminomethyl)isoquinolines in good to high yields.

Graphical abstract: Facile synthesis of 3-(aminomethyl)isoquinolines by copper-catalysed domino four-component coupling and cyclisation

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/B718201E
Article type
Communication
Submitted
26 Nov 2007
Accepted
12 Dec 2007
First published
04 Jan 2008

Chem. Commun., 2008, 835-837

Permissions

Request permissions

Facile synthesis of 3-(aminomethyl)isoquinolines by copper-catalysed domino four-component coupling and cyclisation

Y. Ohta, S. Oishi, N. Fujii and H. Ohno, Chem. Commun., 2008, 835 DOI: 10.1039/B718201E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements