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Issue 23, 2008

Electrochemical parameters and techniques in drug development, with an emphasis on quinones and related compounds

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Abstract

This review article summarizes recent applications of electrochemical techniques to redox-active drug development and mechanistic studies. It includes a general introduction to the use of electrochemistry in biology, with a focus on how electrochemistry can uniquely provide both kinetic and thermodynamic information. A number of studies are reported from the literature and the authors’ laboratories, including the investigation of reactive oxygen species, biooxidative/bioreductive activation of pro-drugs, and DNA alkylation, with a particular emphasis on quinones and related compounds. Data from techniques ranging from traditional cyclic voltammetry to sophisticated single cell studies are presented. The examples herein presented illustrate how electrochemical, biochemical and medical knowledge can be integrated to develop strategies for the design and development of redox-selective therapeutics.

Graphical abstract: Electrochemical parameters and techniques in drug development, with an emphasis on quinones and related compounds

Article information


Submitted
22 Nov 2007
Accepted
12 Feb 2008
First published
10 Apr 2008

Chem. Commun., 2008, 2612-2628
Article type
Feature Article

Electrochemical parameters and techniques in drug development, with an emphasis on quinones and related compounds

E. A. Hillard, F. C. de Abreu, D. C. M. Ferreira, G. Jaouen, M. O. F. Goulart and C. Amatore, Chem. Commun., 2008, 2612 DOI: 10.1039/B718116G

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