Issue 47, 2007
From the journal:

Chemical Communications

Construction of a small-molecule-integrated semisynthetic split intein for in vivoprotein ligation†

Tomomi Ando,a   Shinya Tsukiji,a   Tsutomu Tanakaa  and  Teruyuki Nagamune*abc  

* Corresponding authors

a Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan

b Department of Bioengineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan
E-mail: nagamune@bioeng.t.u-tokyo.ac.jp
Fax: +81-3-5841-8657
Tel: +81-3-5841-7328

c Center for NanoBio Integration, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan

Abstract

A new split intein-based protein ligation tool that is synthetically accessible and can be used for protein semisynthesis on the cell surface and potentially inside cells has been constructed.

Graphical abstract: Construction of a small-molecule-integrated semisynthetic split intein for in vivoprotein ligation

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Article information

DOI
https://doi.org/10.1039/B712843F
Article type
Communication
Submitted
22 Aug 2007
Accepted
17 Sep 2007
First published
10 Oct 2007

Chem. Commun., 2007, 4995-4997

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Construction of a small-molecule-integrated semisynthetic split intein for in vivoprotein ligation

T. Ando, S. Tsukiji, T. Tanaka and T. Nagamune, Chem. Commun., 2007, 4995 DOI: 10.1039/B712843F

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