Issue 33, 2007
From the journal:

Chemical Communications

Guanine binding to dirhodium tetracarboxylate anticancer complexes: quantum chemical calculations unravel an elusive mechanism†‡

Dirk V. Deubel§*a  and  Helen T. Chifotidesb  

* Corresponding authors

a ETH Zurich, D-CHAB, Switzerland
E-mail: metals-in-medicine@phys.chem.ethz.ch

b Texas A&M Univ, Department of Chemistry, College Station TX, USA

Abstract

The reaction mechanism leading to metalated DNA fragments in which guanine-N7,O6 spans the metal–metal bond of dirhodium antitumour complexes in a bridging fashion at equatorial sites has been unravelled by a comprehensive prediction of intermediates and transition states.

Graphical abstract: Guanine binding to dirhodium tetracarboxylate anticancer complexes: quantum chemical calculations unravel an elusive mechanism

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Article information

DOI
https://doi.org/10.1039/B709209A
Article type
Communication
Submitted
18 Jun 2007
Accepted
09 Jul 2007
First published
24 Jul 2007

Chem. Commun., 2007, 3438-3440

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Guanine binding to dirhodium tetracarboxylate anticancer complexes: quantum chemical calculations unravel an elusive mechanism

D. V. Deubel and H. T. Chifotides, Chem. Commun., 2007, 3438 DOI: 10.1039/B709209A

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