Responsive fluorinated lanthanide probes for 19F magnetic resonance spectroscopy

P. Kanthi Senanayake; Alan M. Kenwright; David Parker; Susanna K. van der Hoorn

doi:10.1039/B705844F

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Responsive fluorinated lanthanide probes for ¹⁹F magnetic resonance spectroscopy†

P. Kanthi Senanayake,^a Alan M. Kenwright,^a David Parker*^a and Susanna K. van der Hoorn^a

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* Corresponding authors

^a Department of Chemistry, Durham University, South Road, Durham, UK
E-mail: david.parker@dur.ac.uk

Abstract

The introduction of CF₃ reporter groups close to the paramagnetic centre in macrocyclic lanthanide(III) complexes allows faster acquisition of ¹⁹F magnetic resonance data, and amplifies chemical shift non-equivalence, as exemplified by the definition of ratiometric chemical shift probes for pH and, in principle, enzyme activity.

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Supplementary files

Selected details of ligand and complex synthesis; equations defining the factors modulating the electron–nuclear interaction and their effect on R ₁ and R ₂ (chemical exchange, dipolar and Curie mechanisms); examples of the use of emission spectroscopy to measure the protonation constant for [LnL ²]/[LnHL ²] (Ln = Eu, Tb) PDF (167K)

Article information

DOI: https://doi.org/10.1039/B705844F
Article type: Communication
Submitted: 18 Apr 2007
Accepted: 07 Jun 2007
First published: 21 Jun 2007

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Chem. Commun., 2007, 2923-2925

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Responsive fluorinated lanthanide probes for ¹⁹F magnetic resonance spectroscopy

P. K. Senanayake, A. M. Kenwright, D. Parker and S. K. van der Hoorn, Chem. Commun., 2007, 2923 DOI: 10.1039/B705844F

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