Issue 25, 2007
From the journal:

Chemical Communications

Formate as a CO surrogate for cascade processes: Rh-catalyzed cooperative decarbonylation and asymmetric Pauson–Khand-type cyclization reactions†

Hang Wai Lee,a   Albert S. C. Chana  and  Fuk Yee Kwong*a  

* Corresponding authors

a Open Laboratory of Chirotechnology of the Institute of Molecular Technology for Drug Discovery and Synthesis, and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong
E-mail: bcfyk@inet.polyu.edu.hk
Fax: +852 23649932
Tel: +852 34008682

Abstract

A rhodium-(S)-xyl-BINAP complex-catalyzed tandem formate decarbonylation and [2 + 2 + 1] carbonylative cyclization is described; this cooperative process utilizes formate as a condensed CO source, and the newly developed cascade protocol can be extended to its enantioselective version, providing up to 94% ee of the cyclopentenone adducts.

Graphical abstract: Formate as a CO surrogate for cascade processes: Rh-catalyzed cooperative decarbonylation and asymmetric Pauson–Khand-type cyclization reactions

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Article information

DOI
https://doi.org/10.1039/B702718D
Article type
Communication
Submitted
21 Feb 2007
Accepted
09 Mar 2007
First published
30 Mar 2007

Chem. Commun., 2007, 2633-2635

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Formate as a CO surrogate for cascade processes: Rh-catalyzed cooperative decarbonylation and asymmetric Pauson–Khand-type cyclization reactions

H. W. Lee, A. S. C. Chan and F. Y. Kwong, Chem. Commun., 2007, 2633 DOI: 10.1039/B702718D

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