Issue 10, 2007
From the journal:

Chemical Communications

Mito-DEPMPO synthesized from a novel NH2-reactive DEPMPO spin trap: a new and improved trap for the detection of superoxide†

Micael Hardy,a   Florence Chalier,a   Olivier Ouari,a   Jean-Pierre Finet,a   Antal Rockenbauer,b   Balaraman Kalyanaramanc  and  Paul Tordo*a  

* Corresponding authors

a SREP, UMR 6517 CNRS et Universités Aix-Marseille 1, 2 et 3, Centre de Saint Jérôme, 13013 Marseille, France
E-mail: tordo@up.univ-mrs.fr
Fax: +33 491 288 758
Tel: +33 491 106 009

b Chemical Research Center, Institute of Structural Chemistry, PO Box 17, H-1525 Budapest, Hungary

c Dept of Biophysics and Free Radical Research Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
E-mail: balarama@mcw.edu
Tel: +1 414 456-4000

Abstract

Mito-DEPMPO, a new DEPMPO analogue bearing a triphenylphosphonium group, was synthesized via a novel NH2-reactive DEPMPO. The half-life of the Mito-DEPMPOsuperoxide adduct was estimated to be ca. 40 min. Using Mito-DEPMPO, reactive oxygen species generated in intact mitochondria were detected and characterized by EPR.

Graphical abstract: Mito-DEPMPO synthesized from a novel NH2-reactive DEPMPO spin trap: a new and improved trap for the detection of superoxide

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Article information

DOI
https://doi.org/10.1039/B616076J
Article type
Communication
Submitted
03 Nov 2006
Accepted
22 Nov 2006
First published
02 Jan 2007

Chem. Commun., 2007, 1083-1085

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Mito-DEPMPO synthesized from a novel NH2-reactive DEPMPO spin trap: a new and improved trap for the detection of superoxide

M. Hardy, F. Chalier, O. Ouari, J. Finet, A. Rockenbauer, B. Kalyanaraman and P. Tordo, Chem. Commun., 2007, 1083 DOI: 10.1039/B616076J

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