Issue 9, 2007
From the journal:

Chemical Communications

Ligand accelerated indium(iii)-catalyzed asymmetric alkynylation of aldehydes with 2-methyl-3-butyn-2-ol as an ethyne equivalent donor†

Shinji Harada,a   Ryo Takita,a   Takashi Ohshima,a   Shigeki Matsunagaa  and  Masakatsu Shibasaki*a  

* Corresponding authors

a Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan
E-mail: mshibasa@mol.f.u-tokyo.ac.jp
Fax: +81-3-5684-5206
Tel: +81-3-5841-4830

Abstract

Indium(III)-catalyzed asymmetric alkynylation of aryl, heteroaryl, alkyl and alkenyl aldehydes with 2-methyl-3-butyn-2-ol as an ethyne equivalent donor was realized, and products were obtained in moderate to good yields (up to 97%) and high enantioselectivities (up to 99% ee) using 2–10 mol% of catalyst.

Graphical abstract: Ligand accelerated indium(iii)-catalyzed asymmetric alkynylation of aldehydes with 2-methyl-3-butyn-2-ol as an ethyne equivalent donor

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/B614958H
Article type
Communication
Submitted
13 Oct 2006
Accepted
10 Nov 2006
First published
01 Dec 2006

Chem. Commun., 2007, 948-950

Permissions

Request permissions

Ligand accelerated indium(III)-catalyzed asymmetric alkynylation of aldehydes with 2-methyl-3-butyn-2-ol as an ethyne equivalent donor

S. Harada, R. Takita, T. Ohshima, S. Matsunaga and M. Shibasaki, Chem. Commun., 2007, 948 DOI: 10.1039/B614958H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements