Issue 3, 2007
From the journal:

Chemical Communications

Synthesis of rigidly-linked vancomycin dimers and their in vivo efficacy against resistant bacteria†

Jun Lu,a   Osamu Yoshida,b   Sayaka Hayashic  and  Hirokazu Arimoto*c  

* Corresponding authors

a Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa, Nagoya, Japan

b Discovery Research Laboratories, Shionogi & Co., Ltd., Fukushima, Osaka, Japan

c Graduate School of Life Sciences, Tohoku University, Sendai, Japan
E-mail: arimoto@biochem.tohoku.ac.jp
Fax: +81 22 717 8806
Tel: +81 22 717 8803

Abstract

A novel and efficient avenue for the preparation of dimeric vancomycins is described, and the dimers exhibited excellent antibacterial activities in the murine infection model.

Graphical abstract: Synthesis of rigidly-linked vancomycin dimers and their in vivo efficacy against resistant bacteria

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Article information

DOI
https://doi.org/10.1039/B613319C
Article type
Communication
Submitted
13 Sep 2006
Accepted
10 Oct 2006
First published
24 Oct 2006

Chem. Commun., 2007, 251-253

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Synthesis of rigidly-linked vancomycin dimers and their in vivo efficacy against resistant bacteria

J. Lu, O. Yoshida, S. Hayashi and H. Arimoto, Chem. Commun., 2007, 251 DOI: 10.1039/B613319C

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