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Issue 28, 2006
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Concise and diversity-oriented synthesis of novel scaffolds embedded with privileged benzopyran motif

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Abstract

A branching DOS strategy for an unbiased natural product-like library with embedded privileged benzopyran motif was established to provide complexity and diversity of resulting heterocycles with desired drug-likeness. The importance of skeletal diversity conducted on a privileged substructure was demonstrated through the biological evaluation of a small molecule library representing 22 unique core skeletons via in vitro cytotoxicity assay.

Graphical abstract: Concise and diversity-oriented synthesis of novel scaffolds embedded with privileged benzopyran motif

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Publication details

The article was received on 04 May 2006, accepted on 25 May 2006 and first published on 13 Jun 2006


Article type: Communication
DOI: 10.1039/B606341A
Chem. Commun., 2006, 2962-2964

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    Concise and diversity-oriented synthesis of novel scaffolds embedded with privileged benzopyran motif

    S. K. Ko, H. J. Jang, E. Kim and S. B. Park, Chem. Commun., 2006, 2962
    DOI: 10.1039/B606341A

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