Biosynthesis of the angiogenesis inhibitor borrelidin: directed biosynthesis of novel analogues†
Abstract
We report the directed biosynthesis of borrelidin analogues and their selective anti-proliferative activity against human cancer cell lines.
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* Corresponding authors
a
Biotica, Chesterford Research Park, Little Chesterford, UK
E-mail:
barrie.wilkinson@biotica.com
Fax: +44 (0)1799 532920
Tel: +44 (0)1799 532925
b Departamento de Biologia Funciona e Instituto Universitario de Oncologia del Principado de Asturias (I.U.O.P.A.), Universidad de Oviedo, 33006 Oviedo, Spain
c Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, UK
We report the directed biosynthesis of borrelidin analogues and their selective anti-proliferative activity against human cancer cell lines.
S. J. Moss, I. Carletti, C. Olano, R. M. Sheridan, M. Ward, V. Math, M. Nur-E-Alam, A. F. Braña, M. Q. Zhang, P. F. Leadlay, C. Méndez, J. A. Salas and B. Wilkinson, Chem. Commun., 2006, 2341 DOI: 10.1039/B602931K
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