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Issue 11, 2006
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Synthesis of the bicyclic core of tagetitoxin

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Abstract

A synthesis of the 9-oxa-3-thiabicyclo[3.3.1]nonane ring system, which constitutes the core of the RNA polymerase inhibitor tagetitoxin, has been achieved through cyclisation of a thiol onto an electrophilic ketone.

Graphical abstract: Synthesis of the bicyclic core of tagetitoxin

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Supplementary files

Article information


Submitted
19 Jan 2006
Accepted
31 Jan 2006
First published
14 Feb 2006

Chem. Commun., 2006, 1197-1199
Article type
Communication

Synthesis of the bicyclic core of tagetitoxin

J. R. H. Plet and M. J. Porter, Chem. Commun., 2006, 1197
DOI: 10.1039/B600819D

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