Issue 12, 2006
From the journal:

Chemical Communications

Enzyme stabilizer DTT catalyzes nitrilase analogue hydrolysis of nitriles

Margit Winkler,a   Anton Gliederb  and  Norbert Klempier*a  

* Corresponding authors

a Institute of Organic Chemistry, Graz University of Technology, Stremayrgasse 16/II, Graz, Austria
E-mail: klempier@tugraz.at
Fax: ++43 316 873 8740
Tel: ++43 316 873 8245

b Institute of Molecular Biotechnology, Graz University of Technology, Petersgasse 14/II, Graz, Austria
E-mail: glieder@glieder.com
Fax: ++43 316 873 4072
Tel: ++43 316 873 4074

Abstract

Amides are the dominating products in some nitrilase catalyzed conversions of α-activated nitriles, but unexpectedly this hydrolytic reaction is also catalyzed by 1,4-dithio-DL-threitol (DTT), a standard antioxidizing enzyme stabilizer.

Graphical abstract: Enzyme stabilizer DTT catalyzes nitrilase analogue hydrolysis of nitriles

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Article information

DOI
https://doi.org/10.1039/B516937B
Article type
Communication
Submitted
29 Nov 2005
Accepted
23 Jan 2006
First published
10 Feb 2006

Chem. Commun., 2006, 1298-1300

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Enzyme stabilizer DTT catalyzes nitrilase analogue hydrolysis of nitriles

M. Winkler, A. Glieder and N. Klempier, Chem. Commun., 2006, 1298 DOI: 10.1039/B516937B

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