Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 11, 2006
Previous Article Next Article

Direct enantio- and diastereoselective Mannich reactions of malonate and β-keto esters with N-Boc and N-Cbz aldimines catalysed by a bifunctional cinchonine derivative

Author affiliations

Abstract

A highly enantioselective Mannich reaction between malonate esters and N-Boc and N-Cbz aldimines, catalysed by a bifunctional cinchonine derivative, has been developed; extension of this methodology to encompass the use of 2-substituted-1,3-dicarbonyl nucleophiles allows the formation of adjacent stereocentres, one of which is quaternary, in high relative and absolute stereocontrol.

Graphical abstract: Direct enantio- and diastereoselective Mannich reactions of malonate and β-keto esters with N-Boc and N-Cbz aldimines catalysed by a bifunctional cinchonine derivative

Back to tab navigation

Supplementary files

Article information


Submitted
04 Nov 2005
Accepted
20 Dec 2005
First published
01 Feb 2006

Chem. Commun., 2006, 1191-1193
Article type
Communication

Direct enantio- and diastereoselective Mannich reactions of malonate and β-keto esters with N-Boc and N-Cbz aldimines catalysed by a bifunctional cinchonine derivative

A. L. Tillman, J. Ye and D. J. Dixon, Chem. Commun., 2006, 1191
DOI: 10.1039/B515725K

Social activity

Search articles by author

Spotlight

Advertisements