Issue 5, 2006
From the journal:

Chemical Communications

One pot synthesis of selenocysteine containing peptoid libraries by Ugi multicomponent reactions in water†

Muhammad Abbas,a   John Bethkea  and  Ludger A. Wessjohann*a  

* Corresponding authors

a Leibniz Institute of Plant Biochemistry, Department of Bioorganic Chemistry, Weinberg 3, D-06120 Halle (Saale), Germany
E-mail: wessjohann@ipb-halle.de
Fax: +49 345 5582 1309;
Tel: +49 345 5582 1301

Abstract

Selenocysteine containing peptoids and peptide–peptoid conjugates were synthesized by combinatorial Ugi-MCRs (multicomponent reactions) in water: for the first time, an acetal (selenoacetal 2a) was used in Ugi-MCR to furnish selenocysteine peptoids in one step as model compounds for selenocysteine peptides and proteins.

Graphical abstract: One pot synthesis of selenocysteine containing peptoid libraries by Ugi multicomponent reactions in water

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Article information

DOI
https://doi.org/10.1039/B514597J
Article type
Communication
Submitted
14 Oct 2005
Accepted
22 Nov 2005
First published
15 Dec 2005

Chem. Commun., 2006, 541-543

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One pot synthesis of selenocysteine containing peptoid libraries by Ugi multicomponent reactions in water

M. Abbas, J. Bethke and L. A. Wessjohann, Chem. Commun., 2006, 541 DOI: 10.1039/B514597J

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