Issue 1, 2006
From the journal:

Chemical Communications

Screening for crystalline salts via mechanochemistry†

Andrew V. Trask,a   Delia A. Haynes,a   W. D. Samuel Motherwellb  and  William Jones*a  

* Corresponding authors

a Pfizer Institute for Pharmaceutical Materials Science, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK
E-mail: wj10@cam.ac.uk
Fax: +44 (0)1223 336362
Tel: +44 (0)1223 336468

b Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge, UK

Abstract

Neat grinding and solvent-drop grinding methods are found to be effective screening tools for indicating the potential for crystalline salt formation involving a given acid–base pair, as demonstrated with two model pharmaceuticals.

Graphical abstract: Screening for crystalline salts via mechanochemistry

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Article information

DOI
https://doi.org/10.1039/B512626F
Article type
Communication
Submitted
08 Sep 2005
Accepted
31 Oct 2005
First published
21 Nov 2005

Chem. Commun., 2006, 51-53

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Screening for crystalline salts via mechanochemistry

A. V. Trask, D. A. Haynes, W. D. S. Motherwell and W. Jones, Chem. Commun., 2006, 51 DOI: 10.1039/B512626F

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