Conformational and spacial preferences for substrates of PepT1

Patrick D. Bailey; C. A. Richard Boyd; Ian D. Collier; John. G. George; George L. Kellett; David Meredith; Keith M. Morgan; Rachel Pettecrew; Richard A. Price; Robin G. Pritchard

doi:10.1039/B510697D

Conformational and spacial preferences for substrates of PepT1

Patrick D. Bailey,*^a C. A. Richard Boyd,^b Ian D. Collier,†^c John. G. George,^c George L. Kellett,^d David Meredith,^b Keith M. Morgan,^c Rachel Pettecrew,^a Richard A. Price^a and Robin G. Pritchard^a

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^a School of Chemistry, Faraday Building, The University of Manchester, Sackville Street, Manchester, UK
E-mail: pat.bailey@manchester.ac.uk
Fax: (0161) 306 4541
Tel: (0161) 306 4448

^b Dept. of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, UK

^c Department of Chemistry, Heriot-Watt University, Edinburgh, UK

^d Department of Biology, University of York (Area 3), Heslington, York, UK

Abstract

The conformation at the first residue of dipeptide substrates for the peptide transporter PepT1 has been probed using constrained peptide analogues, and the active conformation has been identified.

Chemical Communications

Conformational and spacial preferences for substrates of PepT1

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Conformational and spacial preferences for substrates of PepT1

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