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Issue 29, 2005
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Synthesis of a caged glutamate for efficient one- and two-photon photorelease on living cells

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Abstract

We have synthesized a biologically inert, photosensitive derivative of the major excitatory amino acid, L-glutamate (which we call MDNI-glu) that makes more efficient use of incident light than all other caged glutamates. Laser flash photolysis of MDNI-glu in acutely isolated hippocampal brain slices evoked a rapid increase in intracellular Ca2+ concentration in astrocytes.

Graphical abstract: Synthesis of a caged glutamate for efficient one- and two-photon photorelease on living cells

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Publication details

The article was received on 07 Apr 2005, accepted on 17 May 2005 and first published on 13 Jun 2005


Article type: Communication
DOI: 10.1039/B504922A
Citation: Chem. Commun., 2005,0, 3664-3666
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    Synthesis of a caged glutamate for efficient one- and two-photon photorelease on living cells

    O. D. Fedoryak, J. Sul, P. G. Haydon and G. C. R. Ellis-Davies, Chem. Commun., 2005, 0, 3664
    DOI: 10.1039/B504922A

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