Issue 24, 2005
From the journal:

Chemical Communications

Dynamic kinetic resolution of N-Boc-2-lithiopyrrolidine

Iain Coldham,*a   Jignesh J. Patela  and  Graciela Sanchez-Jimeneza  

* Corresponding authors

a Department of Chemistry, University of Sheffield, Brook Hill, Sheffield, UK
E-mail: i.coldham@sheffield.ac.uk
Fax: +44 (0)114 222 9346
Tel: +44 (0)114 222 9428

Abstract

Asymmetric substitution of the organolithium derived either from N-Boc-2-tributylstannylpyrrolidine by tin–lithium exchange or from N-Boc-pyrrolidine by deprotonation occurs in the presence of a commercially available chiral diamine ligand with high levels of enantioselectivity by a dynamic kinetic resolution pathway.

Graphical abstract: Dynamic kinetic resolution of N-Boc-2-lithiopyrrolidine

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Article information

DOI
https://doi.org/10.1039/B504015A
Article type
Communication
Submitted
21 Mar 2005
Accepted
22 Apr 2005
First published
11 May 2005

Chem. Commun., 2005, 3083-3085

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Dynamic kinetic resolution of N-Boc-2-lithiopyrrolidine

I. Coldham, J. J. Patel and G. Sanchez-Jimenez, Chem. Commun., 2005, 3083 DOI: 10.1039/B504015A

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