Issue 28, 2005

Physiologically stable vanadium(iv) porphyrins as a new class of anti-HIV agents

Abstract

The water soluble oxovanadium(IV) tetraarylporphyrin 1a has demonstrated excellent solution stability against glutathione reduction and high potency (5 µM, 97% inhibition) in inhibiting HIV-1 replication in Hut/CCR5 cells.

Graphical abstract: Physiologically stable vanadium(iv) porphyrins as a new class of anti-HIV agents

Supplementary files

Article information

Article type
Communication
Submitted
10 Mar 2005
Accepted
04 May 2005
First published
01 Jun 2005

Chem. Commun., 2005, 3544-3546

Physiologically stable vanadium(IV) porphyrins as a new class of anti-HIV agents

S. Wong, R. Wai-Yin Sun, N. P.-Y. Chung, C. Lin and C. Che, Chem. Commun., 2005, 3544 DOI: 10.1039/B503535J

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