Issue 15, 2005

Expanding diversity in dynamic combinatorial libraries: simultaneous exchange of disulfide and thioester linkages

Abstract

Dynamic combinatorial libraries have been prepared which feature two simultaneous covalent exchange reactions in aqueous solution at neutral pH. This allows for diversity, not only of the subunits that are linked, but also of the linkage itself.

Graphical abstract: Expanding diversity in dynamic combinatorial libraries: simultaneous exchange of disulfide and thioester linkages

Supplementary files

Article information

Article type
Communication
Submitted
14 Jan 2005
Accepted
09 Feb 2005
First published
18 Feb 2005

Chem. Commun., 2005, 1959-1961

Expanding diversity in dynamic combinatorial libraries: simultaneous exchange of disulfide and thioester linkages

J. Leclaire, L. Vial, S. Otto and J. K. M. Sanders, Chem. Commun., 2005, 1959 DOI: 10.1039/B500638D

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