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Issue 22, 2005
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Promotion of stable triplex formation by partial incorporation of 2′,5′-phosphodiester linkages into triplex-forming oligonucleotides

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Abstract

Pentadecamer homopyrimidine oligonucleotides containing three or more 2′,5′-phosphodiester linkages in different modes were prepared and used to evaluate the ability as a triplex-forming oligonucleotide (TFO), and it was found that discontinuous replacement of the 3′,5′-phosphodiester linkages in TFO by 2′,5′-linkages significantly stabilizes parallel-motif triplexes.

Graphical abstract: Promotion of stable triplex formation by partial incorporation of 2′,5′-phosphodiester linkages into triplex-forming oligonucleotides

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Supplementary files

Article information


Submitted
24 Nov 2004
Accepted
08 Apr 2005
First published
21 Apr 2005

Chem. Commun., 2005, 2793-2795
Article type
Communication

Promotion of stable triplex formation by partial incorporation of 2′,5′-phosphodiester linkages into triplex-forming oligonucleotides

S. Obika, A. Hiroto, O. Nakagawa and T. Imanishi, Chem. Commun., 2005, 2793
DOI: 10.1039/B417688J

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