Issue 20, 2003

Synthesis and reactivity of enediynyl amino acids and peptides: a novel concept in lowering the activation energy of Bergman cyclisation by H-bonding and electrostatic interactions

Abstract

Novel enediynyl amino acids and peptides 3 and 5–8 were synthesized and their thermal reactivity towards Bergman cyclization studied and compared with the earlier reported amino acid 4, which demonstrated, for the first time, the effect of H-bonding and electrostatic interactions in lowering the activation energy of Bergman cyclization.

Graphical abstract: Synthesis and reactivity of enediynyl amino acids and peptides: a novel concept in lowering the activation energy of Bergman cyclisation by H-bonding and electrostatic interactions

Supplementary files

Article information

Article type
Communication
Submitted
29 Jul 2003
Accepted
29 Aug 2003
First published
12 Sep 2003

Chem. Commun., 2003, 2614-2615

Synthesis and reactivity of enediynyl amino acids and peptides: a novel concept in lowering the activation energy of Bergman cyclisation by H-bonding and electrostatic interactions

A. Basak, S. Sekhar Bag and H. M. M. Bdour, Chem. Commun., 2003, 2614 DOI: 10.1039/B308976M

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