Issue 13, 2003

Monacolin N, a compound resulting from derailment of type I iterative polyketide synthase function en route to lovastatin

Abstract

A novel compound, monacolin N, has been isolated from fermentation cultures of Aspergillus nidulans in which the lovastatin polyketide synthase genes lovB and lovC are heterologously expressed.

Graphical abstract: Monacolin N, a compound resulting from derailment of type I iterative polyketide synthase function en route to lovastatin

Supplementary files

Article information

Article type
Communication
Submitted
21 Feb 2003
Accepted
02 May 2003
First published
23 May 2003

Chem. Commun., 2003, 1492-1493

Monacolin N, a compound resulting from derailment of type I iterative polyketide synthase function en route to lovastatin

J. L. Sorensen and J. C. Vederas, Chem. Commun., 2003, 1492 DOI: 10.1039/B304252A

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