Issue 11, 2003
From the journal:

Chemical Communications

Extra amino group-containing gramicidin S analogs possessing outer membrane-permeabilizing activity

Masao Kawai,*a   Ryoji Tanaka,a   Hatsuo Yamamura,a   Keiko Yasuda,b   Shizuto Narita,a   Hiroshi Umemoto,a   Setsuko Andoc  and  Takashi Katsub  

* Corresponding authors

a Department of Applied Chemistry, Nagoya Institute of Technology, Nagoya 466-8555, Japan
E-mail: kawai@ach.nitech.ac.jp
Fax: 81 52 735 5215
Tel: 81 52 735 5215

b Faculty of Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan
E-mail: katsu@pheasant.pharm.okayama-u.ac.jp
Fax: 81 86 251 7926
Tel: 81 86 251 7955

c Faculty of Science, Fukuoka University, Fukuoka 814-0180, Japan
E-mail: andos@fukuoka-u.ac.jp
Fax: 81 92 865 6030
Tel: 81 92 871 6631

Abstract

Novel (2S,4R)- and (2S,4S)-4-aminoproline residue-containing analogs of the cyclic decapeptide antibiotic gramicidin S were synthesized, which exhibited marked permeabilizing activity on the outer membrane of gram-negative bacteria.

Graphical abstract: Extra amino group-containing gramicidin S analogs possessing outer membrane-permeabilizing activity

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Article information

DOI
https://doi.org/10.1039/B302351F
Article type
Communication
Submitted
28 Feb 2003
Accepted
20 Mar 2003
First published
29 Apr 2003

Chem. Commun., 2003, 1264-1265

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Extra amino group-containing gramicidin S analogs possessing outer membrane-permeabilizing activity

M. Kawai, R. Tanaka, H. Yamamura, K. Yasuda, S. Narita, H. Umemoto, S. Ando and T. Katsu, Chem. Commun., 2003, 1264 DOI: 10.1039/B302351F

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