Issue 11, 2003
From the journal:

Chemical Communications

Improved biotransformations on charged PEGA supports

Alessandra Basso,a   Luigi De Martin,a   Lucia Gardossi,*a   Graham Margetts,b   Ian Brazendale,b   Annie Y. Bosma,c   Rein V. Ulijn*c  and  Sabine L. Flitschc  

* Corresponding authors

a Dipartimento di Scienze Farmaceutiche, Università degli Studi, Piazzale Europa 1, 34127, Trieste, (Italy)
E-mail: gardossi@units.it
Fax: +39/04052572
Tel: +39/0405583110

b Polymer Laboratories Ltd., Essex Road, Church Stretton, Shropshire, UK

c School of Chemistry, The Edinburgh Centre for Protein Technology, The University of Edinburgh, King's Buildings, West Mains Road, Edinburgh EH9 3JJ, UK
E-mail: rein.ulijn@ed.ac.uk
Tel: +44/01316504792

Abstract

PEGA supports functionalised with permanent charges show superior swelling properties in aqueous media when compared to neutral PEGA; a novel positively charged PEGA resin significantly improves penicillin G amidase (PGA) catalysed biotransformation on solid support, by favouring accessibility of the negatively charged enzyme.

Graphical abstract: Improved biotransformations on charged PEGA supports

About
Cited by
Related
Download options Please wait...

Article information

DOI
https://doi.org/10.1039/B301680C
Article type
Communication
Submitted
13 Feb 2003
Accepted
07 Apr 2003
First published
07 May 2003

Chem. Commun., 2003, 1296-1297

Permissions

Request permissions

Improved biotransformations on charged PEGA supports

A. Basso, L. D. Martin, L. Gardossi, G. Margetts, I. Brazendale, A. Y. Bosma, R. V. Ulijn and S. L. Flitsch, Chem. Commun., 2003, 1296 DOI: 10.1039/B301680C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements