Issue 10, 2003

Biarylpyrimidines: a new class of ligand for high-order DNA recognition

Abstract

Biarylpyrimidines bearing ω-aminoalkyl substituents have been designed as ligands for high-order DNA structures: spectrophotometric, thermal and competition equilibrium dialysis assays showed that changing the functional group for substituent attachment from thioether to amide switches the structural binding preference from triplex to tetraplex DNA; the novel ligands are non-toxic and moderate inhibitors of human telomerase.

Graphical abstract: Biarylpyrimidines: a new class of ligand for high-order DNA recognition

Supplementary files

Article information

Article type
Communication
Submitted
12 Feb 2003
Accepted
05 Mar 2003
First published
09 Apr 2003

Chem. Commun., 2003, 1160-1161

Biarylpyrimidines: a new class of ligand for high-order DNA recognition

P. M. Murphy, V. A. Phillips, S. A. Jennings, N. C. Garbett, J. B. Chaires, T. C. Jenkins and R. T. Wheelhouse, Chem. Commun., 2003, 1160 DOI: 10.1039/B301554H

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