Issue 6, 2003
From the journal:

Chemical Communications

Site-selective RNA scission at two sites for precise genotyping of SNPs by mass spectrometry†‡

Akinori Kuzuya,a   Ryo Mizoguchi,a   Fumi Morisawaa  and  Makoto Komiyama*a  

* Corresponding authors

a Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo, Japan
E-mail: komiyama@mkomi.rcast.u-tokyo.ac.jp

Abstract

Short RNA fragments containing single nucleotide polymorphism (SNP) sites have been selectively clipped out of substrate RNA by using complementary DNA having two acridine residues and LuIII, and the genotype of the substrate is accurately and easily determined by mass analysis of these fragments.

Graphical abstract: Site-selective RNA scission at two sites for precise genotyping of SNPs by mass spectrometry

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Article information

DOI
https://doi.org/10.1039/B300368J
Article type
Communication
Submitted
10 Jan 2003
Accepted
11 Feb 2003
First published
25 Feb 2003

Chem. Commun., 2003, 770-771

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Site-selective RNA scission at two sites for precise genotyping of SNPs by mass spectrometry

A. Kuzuya, R. Mizoguchi, F. Morisawa and M. Komiyama, Chem. Commun., 2003, 770 DOI: 10.1039/B300368J

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